Title : Hypoxia can impair doxorubicin resistance of non-small cell lung cancer cells by inhibiting MRP1 and P-gp expression and boosting the chemosensitizing effects of MRP1 and P-gp blockers.

Pub. Date : 2016 Oct

PMID : 27306525






2 Functional Relationships(s)
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Protein Name
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1 MRP1 and P-gp targeted therapy using MK571, Verapamil, CoCl2 or ambient hypoxia appeared to be promising in abolishing the DOX efflux and DOX resistance of the NSCLC cells. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens
2 MRP1 and P-gp targeted therapy using MK571, Verapamil, CoCl2 or ambient hypoxia appeared to be promising in abolishing the DOX efflux and DOX resistance of the NSCLC cells. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens