Title : Proteomic modulation in breast tumors after metformin exposure: results from a "window of opportunity" trial.

Pub. Date : 2017 Feb

PMID : 27305912






2 Functional Relationships(s)
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1 RESULTS: After adjusting for multiple comparisons in the 32 tumors from metformin-treated patients vs. 34 untreated historical controls, 11 proteins were significantly different between cases vs. CONTROLS: increases in Raptor, C-Raf, Cyclin B1, Cyclin D1, TRFC, and Syk; and reductions in pMAPKpT202,Y204, JNKpT183,pT185, BadpS112, PKC.alphapS657, and SrcpY416. Metformin cyclin D1 Homo sapiens
2 Cyclin D1 change after metformin by IHC was not observed. Metformin cyclin D1 Homo sapiens