Pub. Date : 2016
PMID : 27305147
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. | argatroban | coagulation factor II, thrombin | Homo sapiens |
| 2 | To address this gap, we used surface plasmon resonance to determine the effects of dabigatran and argatroban, active site-directed inhibitors, on thrombin binding to immobilized gammaA/gammaA-fibrin or glycoprotein Ibalpha peptide via exosite 1 and 2, respectively, and thrombin binding to gammaA/gamma"-fibrin or factor Va, which is mediated by both exosites. | argatroban | coagulation factor II, thrombin | Homo sapiens |