Title : Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.

Pub. Date : 2016 Jun 28

PMID : 27298364






2 Functional Relationships(s)
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1 Systemic administration of the high-affinity Sig1R ligand (+)-pentazocine [(+)-PTZ] to rd10 mice over several weeks led to the rescue of cone function as indicated by electroretinographic recordings using natural noise stimuli and preservation of cone cells upon spectral domain optical coherence tomography and retinal histological examination. Pentylenetetrazole sigma non-opioid intracellular receptor 1 Mus musculus
2 The protective effect appears to result from the activation of Sig1R, because rd10/Sig1R(-/-) mice administered (+)-PTZ exhibited no cone preservation. Pentylenetetrazole sigma non-opioid intracellular receptor 1 Mus musculus