Title : The Effect of the APOE4 Gene on Accumulation of Aβ40 After Brain Injury Cannot Be Reversed by Increasing apoE4 Protein.

Pub. Date : 2016 Aug

PMID : 27297672






3 Functional Relationships(s)
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1 Treatment of APOE4 mice with bexarotene for 7 days increased apoE4 protein levels but was not sufficient to reduce TBI-induced Abeta40 Thus, rapid clearance of TBI-induced Abeta40 occurs in mice but these pathways are impaired in APOE4 carriers. Bexarotene apolipoprotein E Homo sapiens
2 Treatment of APOE4 mice with bexarotene for 7 days increased apoE4 protein levels but was not sufficient to reduce TBI-induced Abeta40 Thus, rapid clearance of TBI-induced Abeta40 occurs in mice but these pathways are impaired in APOE4 carriers. Bexarotene apolipoprotein E Homo sapiens
3 Treatment of APOE4 mice with bexarotene for 7 days increased apoE4 protein levels but was not sufficient to reduce TBI-induced Abeta40 Thus, rapid clearance of TBI-induced Abeta40 occurs in mice but these pathways are impaired in APOE4 carriers. Bexarotene apolipoprotein E Homo sapiens