Title : Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse.

Pub. Date : 2016 Oct

PMID : 27291828






1 Functional Relationships(s)
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1 Our results indicate that both donepezil and ABT-239 require the integrity of the brain histaminergic system to exert their procognitive effects and strongly suggest that impairments of PI3K/AKT/GSK-3beta intracellular pathway activation is responsible for the inefficacy of both drugs in histamine-deficient animals. Histamine glycogen synthase kinase 3 beta Mus musculus