Title : Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients.

Pub. Date : 2016 Dec

PMID : 27286724






1 Functional Relationships(s)
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1 (S)-methadone clearance was influenced by cytochrome P450 (CYP) 2B6 activity, ABCB1 3435C>T, and alpha-1 acid glycoprotein level, while (R)-methadone clearance was influenced by CYP2B6 activity, POR*28, and CYP3A4*22. Methadone ATP binding cassette subfamily B member 1 Homo sapiens