Title : p53-independent ibrutinib responses in an Eμ-TCL1 mouse model demonstrates efficacy in high-risk CLL.

Pub. Date : 2016 Jun 10

PMID : 27284738






2 Functional Relationships(s)
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1 We show that ibrutinib was effective in increasing survival, activating cellular programs outside the p53 pathway and did not place selective pressure on the remaining wild-type Trp53 allele. ibrutinib tumor protein p53 Homo sapiens
2 These data provide evidence that ibrutinib acts as an effective treatment for aggressive forms of CLL with TP53 mutations. ibrutinib tumor protein p53 Homo sapiens