Title : Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions.

Pub. Date : 2017 Aug

PMID : 27282888






5 Functional Relationships(s)
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1 Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions. Furosemide solute carrier family 22 member 6 Rattus norvegicus
2 Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions. Furosemide solute carrier family 22 member 6 Rattus norvegicus
3 This study was undertaken to simultaneously evaluate the effects of furosemide pretreatment on organic anion transporter 1 (Oat1) and multidrug resistance protein 2 (Mrp2) renal expressions, on p-aminohippurate (PAH) pharmacokinetics and on renal and urinary PAH levels in rats. Furosemide solute carrier family 22 member 6 Rattus norvegicus
4 This study was undertaken to simultaneously evaluate the effects of furosemide pretreatment on organic anion transporter 1 (Oat1) and multidrug resistance protein 2 (Mrp2) renal expressions, on p-aminohippurate (PAH) pharmacokinetics and on renal and urinary PAH levels in rats. Furosemide solute carrier family 22 member 6 Rattus norvegicus
5 RESULTS: Furosemide pretreatment increased both the expression of Oat1 and Mrp2. Furosemide solute carrier family 22 member 6 Rattus norvegicus