Title : Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

Pub. Date : 2016 Jun 23

PMID : 27281194






2 Functional Relationships(s)
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1 Here we report the crystal structures of the METTL3-METTL14 heterodimer with MTase domains in the ligand-free, S-adenosyl methionine (AdoMet)-bound and S-adenosyl homocysteine (AdoHcy)-bound states, with resolutions of 1.9, 1.71 and 1.61 A, respectively. S-Adenosylmethionine methyltransferase 14, N6-adenosine-methyltransferase subunit Homo sapiens
2 Here we report the crystal structures of the METTL3-METTL14 heterodimer with MTase domains in the ligand-free, S-adenosyl methionine (AdoMet)-bound and S-adenosyl homocysteine (AdoHcy)-bound states, with resolutions of 1.9, 1.71 and 1.61 A, respectively. S-Adenosylmethionine methyltransferase 14, N6-adenosine-methyltransferase subunit Homo sapiens