Pub. Date : 2016 Jun
PMID : 27268766
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The purpose of this study was to evaluate in vitro the influence of the ABCB1 1199G>A SNP on ABCB1 transport activity toward selected TKIs (imatinib, nilotinib and dasatinib) that are currently used in chronic myelogenous leukemia. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The purpose of this study was to evaluate in vitro the influence of the ABCB1 1199G>A SNP on ABCB1 transport activity toward selected TKIs (imatinib, nilotinib and dasatinib) that are currently used in chronic myelogenous leukemia. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Imatinib, nilotinib and dasatinib are transported more efficiently by the ABCB1 variant (Asn400) compared with the wild-type (Ser400) protein. | Imatinib Mesylate | ATP binding cassette subfamily B member 1 | Homo sapiens |