Title : High oxidative stress adversely affects NFκB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia.

Pub. Date : 2016 Aug 31

PMID : 27264783






2 Functional Relationships(s)
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1 Mechanistically, we found that under high oxidative stress condition, S-glutathionylation of NFkappaB (p50 and p65 subunits) severely limits iNOS expression due to its reduced binding to iNOS promoter, which was reversed in presence of DTT. Dithiothreitol nuclear factor kappa B subunit 1 Homo sapiens
2 Mechanistically, we found that under high oxidative stress condition, S-glutathionylation of NFkappaB (p50 and p65 subunits) severely limits iNOS expression due to its reduced binding to iNOS promoter, which was reversed in presence of DTT. Dithiothreitol nuclear factor kappa B subunit 1 Homo sapiens