Pub. Date : 2016 Aug
PMID : 27261537
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1 and CES1 exert an important effect in the metabolism of dabigatran etexilate and allele variants at these two loci are likely to play a pivotal role. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 2 | To investigate whether screening for polymorphisms within the ABCB1 and the CES1 genes would explain a portion of the inter-individual variability in blood concentrations of the active metabolite of dabigatran. | Dabigatran | carboxylesterase 1 | Homo sapiens |
| 3 | The CES1 SNP rs8192935 significantly influenced the dabigatran trough concentrations and carriers of the T allele showed significantly lower concentrations than did carriers of the CC genotype. | Dabigatran | carboxylesterase 1 | Homo sapiens |