Pub. Date : 2016 Aug
PMID : 27251362
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | From 794 natural compounds, kurarinone, a flavanone from Sophora flavescens, strongly potentiated BKCa channels. | kurarinone | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |
| 2 | Whereas kurarinone strongly potentiated the homomeric BKCa channel composed of only the alpha subunit, its effects were much smaller on heteromeric channels coassembled with auxiliary beta subunits. | kurarinone | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |
| 3 | Although the activation kinetics was not altered significantly, the deactivation of BKCa channels was dramatically slowed by kurarinone treatment. | kurarinone | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |
| 4 | At the single-channel level, kurarinone increased the open probability of the BKCa channel without affecting its single-channel conductance. | kurarinone | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |
| 5 | These results indicate that kurarinone can directly potentiate BKCa channels and demonstrate the therapeutic potentials of kurarinone and its derivatives for developing antioveractive bladder medications and supplements. | kurarinone | potassium calcium-activated channel subfamily M alpha 1 | Rattus norvegicus |