Title : Redox-sensitive MAPK and Notch3 regulate fibroblast differentiation and activation: a dual role of ERK1/2.

Pub. Date : 2016 Jul 12

PMID : 27248323






2 Functional Relationships(s)
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1 Our results demonstrated that ROS-dependent activation of p38, JNK1/2 and Notch3 promoted basal and TGF-beta1-induced differentiation and expression of extracellular matrix proteins. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens
2 Our results suggest a novel ROS-mediated shift of dominance from the inhibitory ERK1/2 to the stimulatory p38, JNK1/2 and Notch3 during the pathological progression of IPF. Reactive Oxygen Species mitogen-activated protein kinase 1 Homo sapiens