Pub. Date : 2016
PMID : 27242527
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-kappaB Pathway. | Rifaximin | toll like receptor 4 | Homo sapiens |
| 2 | The expression of TLR4 (-33, -50, and -75%), MyD88 (-29, -60, and -81%) and TAK1 (-37, -63, and -79%) were also reduced with rifaximin versus TcdA treatment. | Rifaximin | toll like receptor 4 | Homo sapiens |
| 3 | CONCLUSION: Rifaximin improved TcdA-induced toxicity in Caco-2 cells by the PXR-dependent TLR4/MyD88/NF-kappaB pathway mechanism, and may be useful in the treatment of CDIs. | Rifaximin | toll like receptor 4 | Homo sapiens |