Title : Simvastatin inhibits CD44 fragmentation in chondrocytes.

Pub. Date : 2016 Aug 15

PMID : 27242325






2 Functional Relationships(s)
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Protein Name
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1 Pre-incubation with simvastatin prior to treatment with IL-1beta + Oncostatin M decreased the level of CD44 fragmentation, decreased the proportion of CD44 that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 and ADAM10. Simvastatin ADAM metallopeptidase domain 10 Homo sapiens
2 Pre-incubation with simvastatin prior to treatment with IL-1beta + Oncostatin M decreased the level of CD44 fragmentation, decreased the proportion of CD44 that transits into the lipid raft fractions, decreased ADAM10 activity and diminished the interaction between CD44 and ADAM10. Simvastatin ADAM metallopeptidase domain 10 Homo sapiens