Title : Foxp3 is a key downstream regulator of p53-mediated cellular senescence.

Pub. Date : 2017 Jan 12

PMID : 27238838






4 Functional Relationships(s)
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1 Furthermore, the elevated ROS levels that accompanied Foxp3 overexpression were paralleled by an increase in p21 expression. Reactive Oxygen Species H3 histone pseudogene 16 Homo sapiens
2 Knockdown of p21 in Foxp3-expressing MEFs abrogated the Foxp3-dependent increase in ROS levels, indicating that Foxp3 acts through the induction of p21 and the subsequent ROS elevation to trigger senescence. Reactive Oxygen Species H3 histone pseudogene 16 Homo sapiens
3 Knockdown of p21 in Foxp3-expressing MEFs abrogated the Foxp3-dependent increase in ROS levels, indicating that Foxp3 acts through the induction of p21 and the subsequent ROS elevation to trigger senescence. Reactive Oxygen Species H3 histone pseudogene 16 Homo sapiens
4 Knockdown of p21 in Foxp3-expressing MEFs abrogated the Foxp3-dependent increase in ROS levels, indicating that Foxp3 acts through the induction of p21 and the subsequent ROS elevation to trigger senescence. Reactive Oxygen Species H3 histone pseudogene 16 Homo sapiens