Pub. Date : 2016 Jul 1
PMID : 27234893
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The new sulfonamides showed excellent inhibition of all three isoforms, with KIs in the range of 0.84-702nM against hCA I, of 0.41-288nM against hCA II and of 5.6-29.2 against the tumor-associated hCA IX, a validated anti-tumor target, with a sulfonamide (SLC-0111) in Phase I clinical trials for the treatment of hypoxic, metastatic solid tumors overexpressing CA IX. | Sulfonamides | carbonic anhydrase 2 | Homo sapiens |
2 | The new sulfonamides showed excellent inhibition of all three isoforms, with KIs in the range of 0.84-702nM against hCA I, of 0.41-288nM against hCA II and of 5.6-29.2 against the tumor-associated hCA IX, a validated anti-tumor target, with a sulfonamide (SLC-0111) in Phase I clinical trials for the treatment of hypoxic, metastatic solid tumors overexpressing CA IX. | Sulfonamides | carbonic anhydrase 2 | Homo sapiens |