Title : Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation.

Pub. Date : 2016 Aug

PMID : 27233942






1 Functional Relationships(s)
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1 Stronger intracellular TrxR inhibition and higher accumulation of ROS (O2( -) and H2O2) are responsible for more effective S-phase arrest and mitochondria-mediated apoptotic induction of A549 cells by PL-CL than PLvia p53-p21-cyclinA/CDK2 and ASK1-JNK/p38 signaling cascade pathways, respectively. Reactive Oxygen Species tumor protein p53 Homo sapiens