Title : Effect of inhibiting N-glycosylation on the stability and binding activity of the low density lipoprotein receptor.

Pub. Date : 1989 May 25

PMID : 2722801






2 Functional Relationships(s)
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1 Tunicamycin, a specific inhibitor of N-glycosylation, was used to study the function of asparagine-linked oligosaccharides of the low density lipoprotein (LDL) receptor in cultured human skin fibroblasts. Tunicamycin low density lipoprotein receptor Homo sapiens
2 However, the LDL receptor produced in tunicamycin-treated cells was smaller in molecular size, and it exhibited an about 50% lower binding capacity when compared with its counterpart synthesized in control cells. Tunicamycin low density lipoprotein receptor Homo sapiens