Pub. Date : 2017 Jan
PMID : 27222484
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 2 | Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 3 | Paroxetine is a selective serotonin reuptake inhibitor which was recently shown to have the ability to directly inhibit GRK2 both in vitro and in vivo. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |
| 4 | At physiologic temperatures, paroxetine inhibits GRK2-dependent phosphorylation of an activated G-protein-coupled receptor with a half maximal inhibitory concentration of 35 micromoles, a substantially greater affinity than for other G protein-coupled receptor kinases. | Paroxetine | G protein-coupled receptor kinase 2 | Homo sapiens |