Pub. Date : 2016 Jul 1
PMID : 27221023
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The casual relationship analysis indicated that andrographolide (10 and 20mug/ml) appeared to exert the proliferation inhibitory effect through suppression of glutathione peroxidase 1 (GPX1) activity and depleting GSH by promoting its efflux in 3T3-L1 preadipocytes, which subsequently resulted in 2.06-2.41 fold increase in ROS accumulation. | andrographolide | glutathione peroxidase 1 | Homo sapiens |
| 2 | The casual relationship analysis indicated that andrographolide (10 and 20mug/ml) appeared to exert the proliferation inhibitory effect through suppression of glutathione peroxidase 1 (GPX1) activity and depleting GSH by promoting its efflux in 3T3-L1 preadipocytes, which subsequently resulted in 2.06-2.41 fold increase in ROS accumulation. | andrographolide | glutathione peroxidase 1 | Homo sapiens |
| 3 | SIGNIFICANCE: Taken together, our study reveals that suppression of GPX1 and GSH depletion by andrographolide seems to play a critical role in the inhibition of 3T3-L1 preadipocytes proliferation, which might have implication for obesity prevention and treatment. | andrographolide | glutathione peroxidase 1 | Homo sapiens |