Title : Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.

Pub. Date : 2016 Jul 1

PMID : 27209231






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Compound 5 inhibited downstream phosphorylation of mTORC1 by blocking leucine-sensing ability of LRS, without affecting the catalytic activity of LRS. Leucine leucyl-tRNA synthetase 1 Homo sapiens