Title : Molecular mechanisms in H2O2-induced increase in AT1 receptor gene expression in cardiac fibroblasts: A role for endogenously generated Angiotensin II.

Pub. Date : 2016 Aug

PMID : 27208880






1 Functional Relationships(s)
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1 Activation of NF-kappaB and AP-1, demonstrated by electrophoretic mobility shift assay, abolition of AT1R expression by their inhibitors, Bay-11-7085 and SR11302, respectively, and luciferase and chromatin immunoprecipitation assays confirmed transcriptional control of AT1R by NF-kappaB and AP-1 in H2O2-treated cells. Hydrogen Peroxide Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens