Title : BLVRB redox mutation defines heme degradation in a metabolic pathway of enhanced thrombopoiesis in humans.

Pub. Date : 2016 Aug 4

PMID : 27207795






1 Functional Relationships(s)
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Protein Name
Organism
1 BLVRB(S111L) encompassed within the substrate/cofactor [alpha/beta dinucleotide NAD(P)H] binding fold is a functionally defective redox coupler using flavin and biliverdin (BV) IXbeta tetrapyrrole(s) and results in exaggerated reactive oxygen species accumulation as a putative metabolic signal leading to differential hematopoietic lineage commitment and enhanced thrombopoiesis. 4,6-dinitro-o-cresol biliverdin reductase B Homo sapiens