Pub. Date : 2016 Jun
PMID : 27206970
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we tested the hypothesis that testosterone alleviated vascular smooth muscle cell (VSMC) senescence and collagen synthesis via growth arrest-specific protein 6 (Gas6)/Axl- and Akt/FoxO1a-dependent pathways. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, when FoxO1a expression was silenced by using a specific siRNA, the inhibitory effect of testosterone on MMP-2 activity was revered as well, that indicated this process was Akt/FoxO1a dependence. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, Gas6/Axl and Akt/FoxO1a were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis. | Testosterone | AKT serine/threonine kinase 1 | Homo sapiens |