Title : Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease.

Pub. Date : 2016 Jun 7

PMID : 27203212






2 Functional Relationships(s)
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1 Furthermore, higher OCPs in adipose tissue led to increase in the expression of hepatic cholesterol transporters ABCG5 and G8 (+34% and +27%, P< 0.01) and higher cholesterol saturation index in gallbladder bile, and induced hepatic fatty acids synthesis, which was further confirmed in HepG2 cells. Cholesterol ATP binding cassette subfamily G member 5 Homo sapiens
2 CONCLUSIONS: OCPs might enhance hepatic secretion of cholesterol into bile via ABCG5/G8 which promoting gallstone disease as well as lipogenesis. Cholesterol ATP binding cassette subfamily G member 5 Homo sapiens