Title : Interactions of C-reactive protein and complement with liposomes.

Pub. Date : 1977 Dec

PMID : 271994






1 Functional Relationships(s)
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1 We conclude that (i) CRP can sensitize appropriate liposomes for complement-dependent damage via the primary complement pathway starting at the level of C1q; (ii) of those studied, liposomes that are most susceptible to membrane damage contain phosphatidylcholine, have a positive charge, and contain a ceramide glycolipid; and (iii) such liposomes also are sensitive, although to a much lesser degree, to complement-dependent lysis initiated in the absence of CRP and involving consumption of terminal in excess of early acting complement components. Phosphatidylcholines C-reactive protein Homo sapiens