Title : TNF-α increases the expression and activity of vitamin D receptor in keratinocytes: role of c-Jun N-terminal kinase.

Pub. Date : 2016 Jan-Dec

PMID : 27195054






1 Functional Relationships(s)
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1 In conclusion, the inflammatory cytokine TNF increases the response of keratinocytes to calcitriol through upregulation of its receptor VDR, which in turn is subject to negative feedback by the hormone accelerating the return of the keratinocyte vitamin D system to its basal activity. Vitamin D tumor necrosis factor Homo sapiens