Pub. Date : 2016
PMID : 27193727
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Treating cells with cisplatin induced reactive oxygen species (ROS), c-JUN N-terminal kinase (JNK), and p38 kinase (p38), but not extracellular signal-regulated kinase (ERK). | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Treating cells with cisplatin induced reactive oxygen species (ROS), c-JUN N-terminal kinase (JNK), and p38 kinase (p38), but not extracellular signal-regulated kinase (ERK). | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Fenofibrate reversed cisplatin-induced JNK and p38 activation, but had no effect on ROS production. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | The findings suggest fenofibrate"s protective effect on cisplatin-induced cytotoxicity is mediated by inhibition of JNK and p38. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |