Title : Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways.

Pub. Date : 2016

PMID : 27193727






5 Functional Relationships(s)
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1 Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways. Cisplatin mitogen-activated protein kinase 8 Homo sapiens
2 Treating cells with cisplatin induced reactive oxygen species (ROS), c-JUN N-terminal kinase (JNK), and p38 kinase (p38), but not extracellular signal-regulated kinase (ERK). Cisplatin mitogen-activated protein kinase 8 Homo sapiens
3 Treating cells with cisplatin induced reactive oxygen species (ROS), c-JUN N-terminal kinase (JNK), and p38 kinase (p38), but not extracellular signal-regulated kinase (ERK). Cisplatin mitogen-activated protein kinase 8 Homo sapiens
4 Fenofibrate reversed cisplatin-induced JNK and p38 activation, but had no effect on ROS production. Cisplatin mitogen-activated protein kinase 8 Homo sapiens
5 The findings suggest fenofibrate"s protective effect on cisplatin-induced cytotoxicity is mediated by inhibition of JNK and p38. Cisplatin mitogen-activated protein kinase 8 Homo sapiens