Title : Induced next-day somnolence in an elderly patient taking suvorexant concomitantly with diltiazem.

Pub. Date : 2016 Aug

PMID : 27191770






1 Functional Relationships(s)
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1 DISCUSSION: Because suvorexant is metabolized by CYP3A4, next-day somnolence could have occurred as a result of increased plasma suvorexant concentration due to CYP3A4 inhibition by diltiazem. Diltiazem cytochrome P450 family 3 subfamily A member 4 Homo sapiens