Pub. Date : 2016 Sep
PMID : 27191504
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irreversible inhibition of the essential nervous system enzyme acetylcholinesterase by organophosphate nerve agents and pesticides may quickly lead to death. | Organophosphates | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | The current lack of published structural data specific to human acetylcholinesterase organophosphate-inhibited and oxime-bound states hinders development of effective medical treatments. | Organophosphates | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. | Organophosphates | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | This appears characteristic of acetylcholinesterase inhibition by organophosphate insecticides but not nerve agents. | Organophosphates | acetylcholinesterase (Cartwright blood group) | Homo sapiens |