Title : Genetic polymorphisms in biotransformation enzymes for benzo[a]pyrene and related levels of benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in Goeckerman therapy.

Pub. Date : 2016 Jul 25

PMID : 27188524






3 Functional Relationships(s)
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Protein Name
Organism
1 CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily B member 1 Homo sapiens
3 CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide cytochrome P450 family 1 subfamily B member 1 Homo sapiens