Title : Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-β against Lymph Node-Derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models.

Pub. Date : 2017 Jan

PMID : 27188205






1 Functional Relationships(s)
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1 MATERIALS AND METHODS: CD can convert a prodrug, 5-fluorocytosine (5-FC), to active 5-fluorouracil, which inhibits tumor growth through the inhibition of DNA synthesis,while IFN-beta also strongly inhibits tumor growth by inducing the apoptotic process. Flucytosine interferon beta 1 Homo sapiens