Title : An additive effect of eplerenone to ACE inhibitor on slowing the progression of diabetic nephropathy in the db/db mice.

Pub. Date : 2016

PMID : 27186263






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1 Renal expressions of TNF-alpha, MCP-1, Nox2 and p47phox and renal TBARS levels, markers of inflammation and oxidative stress, were increased during disease progression in diabetic mice, which were reduced by eplerenone or enalapril given alone and further reduced by the two drugs given in combination. Eplerenone mast cell protease 1 Mus musculus