Pub. Date : 2016 Jul 15
PMID : 27184504
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation. | Dimethyl Fumarate | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | At the same time, decreased activation of caspase-1 was detected in DMF-treated mice, indicating that the NLRP3 inflammasome activation was suppressed. | Dimethyl Fumarate | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | The in vitro study verified a negative regulation of DMF and its intestinal metabolite on NLRP3 inflammasome. | Dimethyl Fumarate | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | Taken together, our results demonstrated the ability of DMF to inhibit NLRP3 inflammasome activation and its potential use in the treatment of NLRP3-associated diseases. | Dimethyl Fumarate | NLR family, pyrin domain containing 3 | Mus musculus |
| 5 | Taken together, our results demonstrated the ability of DMF to inhibit NLRP3 inflammasome activation and its potential use in the treatment of NLRP3-associated diseases. | Dimethyl Fumarate | NLR family, pyrin domain containing 3 | Mus musculus |