Title : Effects of pro-inflammatory cytokines, lipopolysaccharide and COX-2 mediators on human colonic neuromuscular function and epithelial permeability.

Pub. Date : 2016 Jul

PMID : 27177092






1 Functional Relationships(s)
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1 None of the cytokine or LPS explant incubations affected the potency or maximum cholinergic contraction in vitro, and subsequent COX-2 blockade with nimesulide revealed a significant but similar decrease in potency of ACh-evoked contraction in control, LPS and cytokine-incubated muscle strips. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens