Title : Histamine induces NF-κB controlled cytokine secretion by orbital fibroblasts via histamine receptor type-1.

Pub. Date : 2016 Jun

PMID : 27170049






2 Functional Relationships(s)
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1 Histamine stimulated the production of IL-6, IL-8 and CCL2 by orbital fibroblasts, while it had no effect on the production of CCL5, CCL7, CXCL10, CXCL11 and hyaluronan. Histamine C-C motif chemokine ligand 2 Homo sapiens
2 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. Histamine C-C motif chemokine ligand 2 Homo sapiens