Pub. Date : 2016 Aug
PMID : 27168353
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deferoxamine alleviates liver fibrosis induced by CCl4 in rats. | Deferoxamine | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 2 | The present study was designed to investigate the potential antifibrotic and anti-oxidant effects of deferoxamine (DFO), a well-known iron chelator in an experimental rat model of liver injury using carbon tetrachloride (CCl4 ). | Deferoxamine | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 3 | First, the potential effective dose of DFO was screened against CCl4 -induced acute hepatotoxicity. | Deferoxamine | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 4 | It was found that treatment of animals with DFO significantly counteracted the changes in liver function; histopathological lesions and hepatic iron deposition that were induced by CCl4 . | Deferoxamine | C-C motif chemokine ligand 4 | Rattus norvegicus |
| 5 | DFO also significantly counteracted the CCl4 -induced lipid peroxidation increase and reduction in antioxidant activities of superoxide dismutase and glutathione peroxidase enzymes. | Deferoxamine | C-C motif chemokine ligand 4 | Rattus norvegicus |