Title : Mechanisms of skin aging induced by EGFR inhibitors.

Pub. Date : 2016 Oct

PMID : 27165055






1 Functional Relationships(s)
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1 Keratinocytes treated with erlotinib in vitro showed a significant down-modulation of hyaluronan synthases (HAS2 and HAS3), whereas senescence-associated genes (p21, p53, IL-6, maspin) were upregulated, along with a G1 cell cycle arrest and stronger SA beta-Gal activity. Erlotinib Hydrochloride tumor protein p53 Homo sapiens