Pub. Date : 2016 Aug
PMID : 27162022
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol cotreatment resulted inhibition of testicular cytochrome P4501A1 (CYP1A1) expression, which is the major B(a)P metabolizing agent for BPDE-DNA adduct formation. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Resveratrol cotreatment resulted inhibition of testicular cytochrome P4501A1 (CYP1A1) expression, which is the major B(a)P metabolizing agent for BPDE-DNA adduct formation. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Our findings cumulatively suggest that resveratrol inhibits conversion of B(a)P into BPDE by modulating the transcriptional regulation of CYP1A1 and acting as an antioxidant thus prevents B(a)P-induced oxidative stress and testicular apoptosis. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |