Title : All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth.

Pub. Date : 2016 Oct 27

PMID : 27157616






2 Functional Relationships(s)
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1 More importantly, ATRA downregulated the expression of the CSC markers CD44 and ALDH as well as stemness genes such as Klf4 and Sox2 and induced differentiation of tumorspheres. Tretinoin CD44 molecule (Indian blood group) Homo sapiens
2 Finally, 2 weeks of daily ATRA treatment were sufficient to inhibit gastric tumor progression in vivo, which was associated with a decrease in CD44, ALDH1, Ki67 and PCNA expression in the remaining tumor cells. Tretinoin CD44 molecule (Indian blood group) Homo sapiens