Pub. Date : 2016 Jun
PMID : 27149910
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Significant impacts of CYP3A4*1G and CYP3A5*3 genetic polymorphisms on the pharmacokinetics of diltiazem and its main metabolites in Chinese adult kidney transplant patients. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | This study was carried out to investigate the impacts of the CYP3A4*1G and CYP3A5*3 genetic polymorphisms on the trough concentration/dose ratios and pharmacokinetics of diltiazem and its main metabolites in Chinese adult renal transplant patients. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | RESULTS AND DISCUSSION: The dose-adjusted concentrations and pharmacokinetics of diltiazem and its main metabolites were significantly affected by CYP3A4 *1G and CYP3A5*3 alleles. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | The dose-adjusted trough levels and AUC of diltiazem and its main metabolites were significantly lower in CYP3A5*1*1 carriers than in CYP3A5*3 carriers (P < 0 05). | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | The dose-adjusted trough levels and AUC of diltiazem and its main metabolites were significantly lower in CYP3A5*1*1 carriers than in CYP3A5*3 carriers (P < 0 05). | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 6 | WHAT IS NEW AND CONCLUSION: The CYP3A4*1G and CYP3A5*3 genetic polymorphisms are closely related to the trough concentration/dose ratios and pharmacokinetics of diltiazem and its main metabolites in Chinese adult renal transplant patients. | Diltiazem | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |