Title : Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations.

Pub. Date : 2016 May 17

PMID : 27144834






1 Functional Relationships(s)
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1 The tankyrase inhibitor, XAV939, identified in a screen for inhibitors of TEAD transcriptional activity, phenocopied these effects independently of its other known functions by stabilizing angiomotin and sequestering YAP in the cytosol. XAV939 Yes1 associated transcriptional regulator Homo sapiens