Title : Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-α-dependent NF-κB signaling and TGF-β signaling.

Pub. Date : 2016 Jul

PMID : 27138103






3 Functional Relationships(s)
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1 Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-alpha-dependent NF-kappaB signaling and TGF-beta signaling. Deferoxamine transforming growth factor beta 1 Homo sapiens
2 Furthermore, the DFO-treated MDA-MB-231 cells showed increases in both tumor necrosis factor alpha (TNF-alpha)-induced nuclear factor kappa B (NF-kappaB) signaling and transforming growth factor-beta (TGF-beta) signaling, which could contribute to the enhanced cell migration. Deferoxamine transforming growth factor beta 1 Homo sapiens
3 Furthermore, the DFO-treated MDA-MB-231 cells showed increases in both tumor necrosis factor alpha (TNF-alpha)-induced nuclear factor kappa B (NF-kappaB) signaling and transforming growth factor-beta (TGF-beta) signaling, which could contribute to the enhanced cell migration. Deferoxamine transforming growth factor beta 1 Homo sapiens