Title : Ergosterol-loaded poly(lactide-co-glycolide) nanoparticles with enhanced in vitro antitumor activity and oral bioavailability.

Pub. Date : 2016 Jun

PMID : 27133301






1 Functional Relationships(s)
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1 NPs/Erg exerted much stronger cytotoxicity against human cancer cells than the free ergosterol, and showed significantly reduced IC50 values (14.69+-0.48 mug/mL in glioma U251 cells; 9.43+-0.52 mug/mL in breast cancer MCF-7 cells; 4.70+-0.41 mug/mL in hepatoma HepG2 cells). Ergosterol ETS transcription factor ERG Homo sapiens