Pub. Date : 2016 Sep
PMID : 27133199
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Scopoletin, an active principle of tree tobacco (Nicotiana glauca) inhibits human tumor vascularization in xenograft models and modulates ERK1, VEGF-A, and FGF-2 in computer model. | Scopoletin | fibroblast growth factor 2 | Homo sapiens |
| 2 | In computer modeling, scopoletin showed strong ligand affinity and binding energies toward the following angiogenic factors: protein kinase (ERK1), vascular endothelial growth factor A (VEGF-A), and fibroblast growth factor 2 (FGF-2). | Scopoletin | fibroblast growth factor 2 | Homo sapiens |
| 3 | These results suggest that the antitumor activity of scopoletin may be due to its strong anti-angiogenic effect, which may be mediated by its effective inhibition of ERK1, VEGF-A, and FGF-2. | Scopoletin | fibroblast growth factor 2 | Homo sapiens |