Pub. Date : 2017 Feb
PMID : 27128966
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin induces degradation of cyclin D1 via AMPK/GSK3beta axis in ovarian cancer. | Metformin | cyclin D1 | Homo sapiens |
| 2 | Here, we first describe that the anti-cancer effect of metformin is mediated by cyclin D1 deregulation via AMPK/GSK3beta axis in ovarian cancer cells. | Metformin | cyclin D1 | Homo sapiens |
| 3 | Metformin induced the G1 cell cycle arrest, in parallel with a decrease in the protein expressions of cyclin D1 without affecting its transcriptional levels. | Metformin | cyclin D1 | Homo sapiens |
| 4 | Using a proteasomal inhibitor, we could address that metformin-induced decrease in cyclin D1 through the ubiquitin/proteasome process. | Metformin | cyclin D1 | Homo sapiens |
| 5 | Cyclin D1 degradation by metformin requires the activation of GSK3beta, as determined based on the treatment with GSK3beta inhibitors. | Metformin | cyclin D1 | Homo sapiens |
| 6 | These findings suggested that the anticancer effects of metformin was induced due to cyclin D1 degradation via AMPK/GSK3beta signaling axis that involved the ubiquitin/proteasome pathway specifically in ovarian cancer cells. | Metformin | cyclin D1 | Homo sapiens |