Pub. Date : 2014 Jan
PMID : 27128230
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sirolimus, metabolized primarily by intestinal and hepatic CYP3A4, is a substrate for P-glycoprotein. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | CYP3A4 inducers would be expected to decrease sirolimus exposure. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | This open-label, nonrandomized study investigated effects of CYP3A4 induction, by rifampin, on sirolimus pharmacokinetics. | Sirolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |